The presence of IL-2Rα (CD25) and IL-2Rγ (CD132, γc) subunits have also been demonstrated, which together with IL-2Rβ form the functional heterotrimeric IL-2Rαβγ complex involved in the possible direct action of IL-2 on RCC (own unpublished data). The gene discussed is IL2RB; the disease is renal cell carcinoma.