For example, it has been demonstrated that the upregulation of LAG-3 may contribute to the exhaustion of intrahepatic and peripheral hepatitis C virus (HCV)-specific CD8+ T cells [35] and also of peripheral CD8+ T cells involved in the defense against diffuse large B-cell lymphoma (DLBCL) [36]. This evidence concerns the gene LAG3 and diffuse large B-cell lymphoma.