In addition, other factors such as miR-370-3p [61], NIX-mediated mitophagy [62], and p21 (CDKN1A)[63] have been identified as crucial players in glioblastoma pathogenesis, highlighting the complex interplay of genetic alterations in shaping the aggressive behavior of glioblastoma cells in the hypoxic tumor microenvironment. Here, CDKN1A is linked to glioblastoma.