In addition, HIF1α has been associated with the activation of Ror1 transcription to influence cancer progression [18], and it regulates miR-210-3p, CXCR7, CXCR4, IDH1, C-Met, SF/HGF, the S100A4/NMIIA axis, NO, VEGF, BAG3, and TDO2, and influences various aspects of the glioblastoma biology such as angiogenesis, invasion, metabolism and therapy resistance [19,20,21,22,23,24,25,26,27,28,30,31,32,33,34]. This evidence concerns the gene TDO2 and cancer.