Consistent with experiments using cell line derived CM, the mRNA expression for OSTEOCALCIN was 22-fold significantly diminished after co-culture with CM derived from MNCs from patients with myeloid neoplasms, and 63-fold diminished after co-culture with CM derived from MNCs from patients with lymphoid neoplasms (Figure 4F). The gene discussed is BGLAP; the disease is myeloid neoplasm.