Approaching the group of “overlap genes” which were in comparison to the healthy controls differentially expressed in all hematological neoplasms, we found candidates, such as DKK2, PITX2, and TBX15, various HOXA2/3, HOXB2-B8 genes, and BMP5, that are crucially involved in the regulation of cell growth, osteogenesis, and hematopoiesis. This evidence concerns the gene PITX2 and hematopoietic and lymphoid system neoplasm.