Studies, such as those examining the interaction of YY1 with AKIP1, SENP1/METTL3/MYC axis, circPTPRF/miR-1208/YY1 axis, and T7-exo-mediated siYY1 delivery, contribute to unraveling YY1’s role in GBM progression. Here, YY1 is linked to glioblastoma.