ATRX and alpha thalassemia spectrum: Additionally, a recent study investigated the role of ATRX (alpha thalassemia/mental retardation X-linked) and DAXX (death domain-associated protein) tumor suppressor genes’ protein expression by immunohistochemistry and telomere status by telomere-specific fluorescence in situ hybridization in 109 PanNETs from 28 MEN1 patients; ATRX and/or DAXX expression was lost in 6% of PanNETs.