After applying a further stringent selection criterion by filtering out miRNAs with fewer than 12 reads per million and retaining those miRNA::gene pairs if downregulated, miRNAs were described as oncogenic miRNAs, and their putative upregulated target genes had a tumour suppressor role in cancer; vice versa, six (four predicted and two validated) and four (three predicted and one validated) miRNA::mRNA pairs remained in the PI3K-Akt or MAPK/ERK signalling pathways, respectively, as shown in Table S6. Here, AKT1 is linked to cancer.