To understand how BRAF mutation contributes to CRC development, we developed a mouse model in which BRAFV600E expression is driven by Lgr5-cre in Min mice (BRAFFV600ELgr5tm1(Cre/ERT2)CleMinApcΔ716/+, BLM) [27]. The gene discussed is BRAF; the disease is colorectal carcinoma.