To computationally determine if the reduction of cycling tumor stem cells in BLM2 is due to the reduced expression of stemness-related genes, we simulated the over-expression (OE) of Id2, a gene that was mainly expressed in the tumor stem cells of BLM2 tumors (Figure 5H) and was significantly downregulated in tumor stem cells of BLM tumors compared to Min tumors (Figure 5F, Supplemental Figure S5C). Here, ID2 is linked to neoplasm.