Mechanistically, KISIMA—VSV-GP-TAg vaccination not only elicited a strong peripheral antigen-specific CD8 T cell response but also induced a deep remodeling of the tumor microenvironment (TME) by promoting a significant influx of cytotoxic CD8 T cells and cross-presenting dendritic cells and by decreasing the presence of immune suppressive cells such as M2 tumor associated macrophages (TAM-2) and myeloid derived suppressor cells (MDSCs) [7,8]. This evidence concerns the gene CD8A and neoplasm.