Under the new guidelines of cIMPACT-NOW update 6 and the 2021 5th edition of WHO classifications of CNS tumors (WHO2021), a diffuse astrocytoma that is IDHwt and lacks high-grade histopathologic features can be diagnosed as GBM-IDHwt if exhibiting any of the following genetic alterations: TERTp mutations, EGFR amplifications, or whole chromosome +7/−10 copy-number changes [19,20,21,22]. This evidence concerns the gene EGFR and glioblastoma.