ANXA1 and neoplasm: Annexin A1 was significantly downregulated in the serum of all tumor stages compared to controls, except T4 (T1: FC = 0.6, p < 0.05; T2: FC = 0.6, p < 0.01; T3: FC = 0.6, p < 0.01; T4: FC = 1.0, p = ns; Figure 1).