Annexin A1 was significantly downregulated in the whole serum of all tumor sizes compared to controls, except T4 (T1: FC = 0.6, p < 0.05; T2: FC = 0.6, p < 0.01; T3: FC = 0.6, p < 0.01; T4: FC = 1.0, p = ns; Figure 1) ELISAs on exosomes, on the other hand, did show overexpression of ANXA1 in tumor samples compared to controls. The gene discussed is ANXA1; the disease is neoplasm.