BRCA1 and breast cancer: A total of 12 patients (14.6%) remained alive with active disease, while 10 patients (12.2%) had succumbed to breast cancer, 6 of whom presented advanced stages (IIIB, n = 4; IIIC, n = 1; IV, n = 1), and most carried PVs in the BRCA1 (n = 4; 40.0%) and BRCA2 (n = 3; 30.0%) genes.