BRCA2 and breast carcinoma: In this study, we observed that BRCA2 is the most frequently mutated gene, followed by BRCA1. These findings are consistent with global data indicating that PVs in BRCA genes account for a significant proportion of hereditary breast cancer cases [3,16,33,34] and that a higher proportion of PVs in BRCA2 are reported among these cases from Colombia [15], Puerto Rico [35], and Cuba [36], whereas BRCA1 PVs are more frequent in Mexico [37,38], Argentina [39], Brazil [40], and Peru [41].