Mobocertinib (TAK-788), an oral EGFR/HER2 inhibitor targeting exon 20 insertions, demonstrated antitumor activity in a phase I/II trial involving advanced NSCLC patients with EGFR exon 20 insertion, while results from an expansion cohort focusing on patients harbouring HER2 exon 20 alterations are still pending [39,40]. Here, ERBB2 is linked to non-small cell lung carcinoma.