Therefore, in this work, we analyzed the effects of the addition of Navitoclax, an BCL-2 and BCL-xL inhibitor, with Ispinesib, a KSP inhibitor, or Barasertib, an Aurora B inhibitor, on oral cancer cells and showed that it enhanced the therapeutic potential of KSP and Aurora B targeting by increasing cell death during mitosis or post-slippage, respectively. The gene discussed is AURKB; the disease is lip and oral cavity carcinoma.