PIK3CA mutations in breast carcinoma were reported to be a favorable prognostic factor, associated with a low histologic grade [51,52,53,54,55], advanced age at diagnosis [52,54], and the absence of lymph node invasion [52,54], with small tumor size [51,52,56], and with a low proliferation index (Ki67) [51,57]. The gene discussed is MKI67; the disease is breast carcinoma.