In contrast, in hepatocellular carcinoma, CFDP1 overexpression was associated with shorter OS (hazard ratio: 2, p = 0.012) and DFS (hazard ratio: 1.8, p = 0.0099), promoting cancer progression by activating the NEDD4/PTEN/PI3K/AKT signaling pathway [54]. This evidence concerns the gene NEDD4 and hepatocellular carcinoma.