THBS2 and nonpapillary renal cell carcinoma: Furthermore, a 10-gene (COL1A1, COL5A1, COL11A1, FN1, ICAM1, ITGAL, ITGAM, ITGB2, THBS2, and TIMP1) expression signature containing COL5A1 observed in CCRCC patients has been reported to be associated with poor survival (HR: 2.85, p = 5.7 × 10−10) [34].