TIM-3 and Gal-9 have been found to be expressed in a variety of cancers, and the mechanism of immune evasion is likely related to the binding of TIM-3 to Gal-9, which induces T-cell apoptosis and increased expression of TIM-3 on regulatory T-cells, promoting T-cell exhaustion [48]. The gene discussed is LGALS9; the disease is cancer.