SEPTIN7 and hepatocellular carcinoma: As imagining and biochemical markers remain substandard methods for the screening of hepatocellular carcinoma (HCC), an epigenetic-based blood test, HCCBloodTest (Epigenomics AG), has been developed, utilizing NGS bisulfite sequencing targeting the methylation status of the SEPT7 gene [85], achieving, in clinical study NCT03804593, a sensitivity and specificity of 76.7% and 64.1%, respectively.