It has to be noted though that apart from initiating replicative immortality, telomerase seems to play a crucial role in almost all the hallmarks of cancer, ranging from cell growth and proliferation through to the activation of EGFR signaling [182], resistance to apoptosis through activation of NF-kB [183], and the promotion of invasion and metastasis through induction of the epithelial–mesenchymal transition via the Wnt/b-catenin pathway that upregulates Snail-1 and vimentin [184], up to direct and indirect (through Myc) modification of energy metabolism [185]. The gene discussed is EGFR; the disease is cancer.