The toxicity profiles of BTKis are closely linked to their kinase-binding patterns, including both on-target inhibition of BTK and variable off-target inhibition of other kinases, such as interleukin-2-inducible T-cell kinase (ITK), tyrosine kinase expressed in hepatocellular carcinoma (TEC), and epidermal growth factor receptor (EGFR) family kinases. Here, EGFR is linked to hepatocellular carcinoma.