KMT2A and acute lymphoblastic leukemia: The high-risk group criteria were as follows: age > 10 years old, WBC count > 50,000/μL, displaying MLL translocation, bone aspirate showing 5–25% blasts on day 15, manifesting stage 3 CNS changes with ≥5 nucleated cells/μL and ALL blasts detected by cytospinning, and active testicular disease.