Common parameters that are used for risk stratification include histopathological factors (e.g., histological subtype, grade, tumor size, number of metastatic lymph nodes, presence of lymph–vascular invasion (LVI), and tumor-infiltrating lymphocytes (TILs)), hormone receptors (HRs), HER2, Ki67 status, BRCA1/2, and gene expression profiling data [6,7,8,9]. The gene discussed is MKI67; the disease is neoplasm.