TWIST1 binds the CD274 promoter and recruits TIP60-Com to the promoter to robustly upregulate PD-L1 expression, which accelerates the exhaustion and death of the tumor antigen-specific CD8+ effector T cells and prevents the TWIST1-expressing breast cancer cells from been killed by these CD8+ T cells. The gene discussed is TWIST1; the disease is breast carcinoma.