Merlin indirectly links to cell adhesion molecules, receptor tyrosine kinases involved in the reception of extracellular signals, and downstream molecules that regulate intracellular signal transduction cascades (pro-oncogenic or tumor suppressive pathways, e.g., phosphoinositide 3-kinase (PI3K)/Akt, Hippo, and mammalian target of rapamycin (mTOR) pathways), regulating cell survival and proliferation [71,72,73]. Here, AKT1 is linked to neoplasm.