The enzymatic subunit of polycomb repressive complex 2 (PRC2), EZH2, a histone-lysine N-methyltransferase responsible for transcriptional silencing [116], is increased in CTH, CTO, CTP, and CEGBCs cells [64,66,67,69], as reported in several cancers of poor prognosis [117,118,119,120,121,122,123,124]. The gene discussed is EZH2; the disease is cancer.