In the study conducted by Wei et al., circ_0020123 acts as a competitive endogenous RNA (ceRNA) to interact with miR-1283, thus promoting the expression levels of PDZD8, a cytoskeletal regulatory protein involved in tumor migration and proliferation [94], also involved in the LARP1/miR-330-5p tumor axis mechanism with the homonymous CircRNA (circ_PDZD8) [95] or suppressing tumor growth either if not expressed [96] or through sponging miR-1299, regulating HMGB3 [97]. Here, HMGB3 is linked to neoplasm.