ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Most of the previous studies in the field have described positive effects from exercise by increasing circulatory adiponectin in patients with metabolic dysfunctions (i.e., type 2 diabetes) [43], but to the best of our knowledge, this is the first study that explores the effects of two different exercise programs on this protein directly in the tissue; therefore, this differential response between programs could be one of the reasons behind the variability of this response in people with obesity [44].