Independently of the absence of differences between training programs, the question regarding the effects of exercise itself on this protein remains since no untrained control group was included in this trial, along with the levels of its receptor ADIPOR1, considering that in preclinical studies we have seen obesity-related downregulations of both proteins and partial restoration after exercise [13,28]. The gene discussed is ADIPOR1; the disease is obesity due to melanocortin 4 receptor deficiency.