This idea is supported by the findings of Ryan et al., given that when they compared the effects of 12 weeks of MICT and HIIT on the insulin sensitivity of adults with obesity, they described similar effects after both training programs [23], highlighting the possibility that when obesity is involved, the impact of the exercise intensity is not the same as when analyzing healthy subjects [24]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.