Our results show that hepcidin, as well as ferritin, IRF, EPO, CRP, IL-6, ferritin/hepcidin, and hepcidin/iron, were significantly increased, while UIBC, TIBC, hepcidin/CRP, and hepcidin/IL-6 were significantly decreased in hypoxic compared to normoxic patients as well as in patients with severe or critical disease compared to those with mild and moderate COVID-19. This evidence concerns the gene TRIM63 and COVID-19.