In our study, the hepcidin/IL-6 ratio was lower in the hypoxic than in the normoxic group, as well as in severe and critical COVID-19 (where all patients except two were hypoxic), which could further indicate that hepcidin level was not proportional to the level of inflammation in the hypoxic patient group probably due to downregulating effect of hypoxia. This evidence concerns the gene HAMP and COVID-19.