TOMM40 and early-onset autosomal dominant Alzheimer disease: To this point, the TOMM40 SNP rs2075650 has been studied in several works highlighting its critical role in mitochondrial dysfunction in Alzheimer’s disease and cardiac preconditioning, by both impairing mitochondrial Ca2+ signaling and mtPTP (mitochondrial permeability transition pore) opening [25,26,27,28,29,30,31].It is known that different cells of the cardiovascular system (cardiomyocytes, smooth muscle cells, fibroblasts and endothelial cells) depend on the proper functioning of the mitochondrial chain machinery [32].