PRPF6 and heart conduction disease: All these experimental studies open an interesting scenario about the role of TOM complex in connexins regulation, supporting the hypothesis of a “connexin connection” and suggesting a plausible role for TOMM40 SNP in cardiac conduction disease in our study; since Cx43, among other functions, regulates the correct propagation of cardiac impulse, and the Cx43 concentration depends on correct import into mitochondria through TOM23, we can speculate that TOMM40 deficiency may induce a dysfunction of the entire TOM complex with Cx43 downregulation.