INS and obstructive sleep apnea syndrome: Another case–control study of 52 young lean men (with a mean age of 23.4 ± 0.4 years and mean BMI of 22.6 ± 0.3 kg/m2) without cardiometabolic disease reported that participants with OSA had 27% lower insulin sensitivity, estimated by the Matsuda index, and 37% higher insulin secretion after the ingestion of glucose load than those without OSA [7].