Another randomized trial assessed the incremental effect of combined intervention, including a weight loss intervention and CPAP, in which 146 patients with obesity, moderate-to-severe OSA, and serum levels of C-reactive protein (CRP) greater than 1.0 mg/L were allocated to three groups (CPAP alone, weight loss intervention alone, or CPAP with a weight loss intervention) [24]. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.