POU2F3 and small cell lung carcinoma: Since non-neuroendocrine subtypes (especially triple-negative for ASCL1, NEUROD1, and POU2F3) showed more immune infiltration, identifying the genes switching neuroendocrine SCLC to non-neuroendocrine SCLC will be critically important to achieve durable immune therapy response by directing immune “cold” NE to immune “hot” non-NE SCLC.