Since non-neuroendocrine subtypes (especially triple-negative for ASCL1, NEUROD1, and POU2F3) showed more immune infiltration, identifying the genes switching neuroendocrine SCLC to non-neuroendocrine SCLC will be critically important to achieve durable immune therapy response by directing immune “cold” NE to immune “hot” non-NE SCLC. The gene discussed is NEUROD1; the disease is small cell lung carcinoma.