The computational modeling of transcriptomics data has defined SCLC subtypes using the expression of four key transcription factors: achaete-scute homolog 1 (ASCL1), Neuronal Differentiation 1 (NEUROD1), POU class 2 homeobox 3 (POU2F3), and Yes-Associated Protein 1 (YAP1) [60]. This evidence concerns the gene ASCL1 and small cell lung carcinoma.