This has led to the identification of several SCLC subtypes, including SCLC-A (ASCL1-positive), SCLC-N (NEUROD1-positive), SCLC-P (POU2F3-positive), and SCLC-Y (YAP1-positive) or SCLC-inflamed [5,6]. The gene discussed is ASCL1; the disease is small cell lung carcinoma.