ICAM1 and systemic sclerosis: Proadhesive phenotype in SSc skin; induces myeloid cell adhesion to dermal fibroblasts.Leads to accumulation of leukocytes.Accumulation of lymphocytes T may contribute to fibrosis induction through the release of cytokines, which subsequently triggers excessive synthesis of the extracellular matrix.Increased serum levels of soluble ICAM-1 correlate with early stages of the disease and diffuse cutaneous SSc.