Bilophila presence may contribute to pro-inflammatory responses and conditions like inflammatory bowel disease in some individuals [48], the (Ruminococcus) gauvreauii group can enhance systemic immune responses mediated by pro-inflammatory cytokines such as TNF-α and IL-6 h [49], whereas UCG-003 can be associated with chronic insomnia and cardiometabolic diseases [50]. The gene discussed is TNF; the disease is inflammatory bowel disease.