Notably, Guo et al. [93] found an increased expression of NLRP1, NLRP3, NLRC4, AIM2, caspase-1, and precursors of IL-β and IL-18 in thyroid tissues of patients with HT, the first to demonstrate an association between inflammasome and the pathogenesis of HT. Here, CASP1 is linked to hematocrit.