Nayer et al. [169] demonstrated the bond of serum anti-tTG antibodies to tTG located in thyroid tissue and the positive correlation between tTG IgA and TPOAb titers in patients with active CeD, thus speculating a role for anti-tTG antibodies as a contributing factor in the development of thyroid autoimmunity. This evidence concerns the gene TGM2 and autoimmune thyroid disease.