TOR1A and cranioectodermal dysplasia: Hence, the presence of any of the DQ2.5, DQ8, or DQ2.2 heterodimers increases the risk of developing CeD; in particular, the HLA-DQ2.5 heterodimer, one variant of the DQ2 molecule encoded by the DQB1*02 and DQA1*05 alleles, represents the most permissive heterodimer for CeD (encoded by approximately 90% of celiac patients).