Dehzad et al. 2023 [28] showed that curcumin intake of 50–1500 mg/day for 4–42 weeks significantly decreased serum leptin levels in health subjects or subjects with metabolic syndrome, NAFLD, impaired glucose tolerance test (IGTT), prediabetes, T2DM, and major depressive disorder in nine publications [29,30,31,32,33,34,35,36,37] (WMD = −4.46 ng/mL; 95% CI −6.70 to −2.21; p < 0.001; I2 = 96.1%, p < 0.001). The gene discussed is LEP; the disease is prediabetes syndrome.