MVK and obesity due to melanocortin 4 receptor deficiency: -↓ geranylgeranyl diphosphate biosynthesis (hydroxymethyglutaryl–coenzyme A (CoA) reductase).-↓ mevalonate pathway (mevalonate kinase).-↑ phosphatidate metabolism.-↑ CA degradation.-↑ 8,11,14-eicosatrienoic acid (linked with obesity).-↓ Phenyllactic acid (linked with reduced reactive oxygen species).