In addition to inhibiting lipid peroxidation and reducing total cholesterol, vitamin E also attenuates hypertension, platelet aggregation, and levels of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion protein 1 (VCAM-1), and E-selectin, improving NO bioavailability [52,53]. The gene discussed is ICAM1; the disease is Hypertension.