ADIPOQ and obesity due to melanocortin 4 receptor deficiency: The infiltration of immune cells, elevated levels of leptin, resistin, plasminogen activator inhibitor-1 (PAI-1), and pro-inflammatory adipokines, and the decrease in the thermogenesis of adiponectin and brown adipose tissue (BAT) are the main incidences of adipose tissue remodeling in people with obesity.