The infiltration of immune cells, elevated levels of leptin, resistin, plasminogen activator inhibitor-1 (PAI-1), and pro-inflammatory adipokines, and the decrease in the thermogenesis of adiponectin and brown adipose tissue (BAT) are the main incidences of adipose tissue remodeling in people with obesity. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.