A recent report described enhanced IL-6 levels in patients with HF and preserved LVEF; IL-6 was associated with higher BMI, total fat mass, trunk fat mass, as well as with raised serum NT-proBNP, CRP and TNF-α levels; furthermore, it was associated with worse renal function, lower haemoglobin levels, and impaired glucose metabolism [39]. The gene discussed is NPPB; the disease is hydrops fetalis.