Furthermore, older adults with T2DM tend to have diminished levels of cardiorespiratory fitness, which could be associated with losses in bone mineral density since peak oxygen (VO2peak) consumption is one of the strongest predictors of bone variables [10] due to its involvement in the activation of genes related to osteogenesis, such as erythropoietin (EPO) [11]. Here, EPO is linked to type 2 diabetes mellitus.