The synthetic DHCR24 inhibitor SH42 has previously been reported to increase desmosterol levels causing an LXRα-dependent decrease in liver inflammation by preventing Kupffer cell activation and monocyte infiltration in a mouse model of human-like non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) [87]. Here, NR1H3 is linked to metabolic dysfunction-associated steatotic liver disease.