INS and type 1 diabetes mellitus: One of the most important findings of this study is related to the effective achievement of the long-term glycemic control in animals having T1DM and treated with lycopene + 1 U/day insulin; this glycemic control was better than those observed with the isolated therapies, and similar to the glycemic control of the group receiving the standard treatment, the DI4U group, and also similar to the control group, the non-diabetic, NYOG group.