The role of the insulin resistance in the pathophysiology of T1DM is not yet fully understood, but insulin resistance has been associated with an inefficient glycemic control, culminating in the need for a gradual increase in the insulin dose in patients with T1DM to achieve the glycemic control, which in turn has, as a main consequence, the risk of hypoglycemia [1,2]. The gene discussed is INS; the disease is Hypoglycemia.