SERPINE1 and Hyperglycemia: Earlier studies indicate that chronic hyperglycemia induces ED through varied pathways: heightened reactive oxygen species (ROS) from hyperglycemia, elevated transforming growth factor-β and plasminogen activator inhibitor-1, and diminished NO availability impacting both macrovascular and microvascular function [1] As expected, our study found elevated fasting glucose and HbA1C level are inversely related to vascular reactivity in T2DM patients.