INS and hyperinsulinemic hypoglycemia, familial, 4: As regards the ubiquitous expression of VDR, and, in particular, in insulin-sensitive tissues, a study analyzing human and rodent data showed that: (1) 25OHD repletion in insulin-resistant, overweight-to-obese persons was associated with reductions in subcutaneous adipose tissue expression of pro-inflammatory and profibrotic genes, decreased collagen immunofluorescence, and improved hepatic insulin sensitivity as well as worsening trends after six months on the placebo suggesting progressive metabolic effects of 25OHD deficiency.