A circulatory endothelin 1-regulating RNAs panel composed of EDN1/TNF/MAPK3/EP300/hsa-miR-6888-5p/lncRNA RABGAP1L-DT-206 showed positive regulation in patients with MASLD/MASH compared to controls, thus potentially serving as a tool for the early diagnosis and stratification of hepatic fibrosis in MASLD/MASH patients [87]. This evidence concerns the gene MAPK3 and metabolic dysfunction-associated steatotic liver disease.