CAT and COVID-19: For example, a multi-enzyme formulation (ImmunoSEB) consisting of probiotic (ProbioSEB CSC3), containing a blend of Bacillus coagulans LBSC (DSM 17654), Bacillus subtilis PLSSC (ATCC SD 7280) and Bacillus clausii 088AE (MCC 0538) strains along with Peptizyme SP, including enteric coated serratiopeptidase, bromelain, amylase, lysozyme, peptidase, catalase, papain, glucoamylase and lactoferrin, significantly reduced total physical and mental fatigue scores in patients with COVID-19 compared with placebo.