IGHE and allergic disease: Regarding the immune mechanisms by which ASC-derived EVs regulate allergic airway diseases, the microRNAs and pulmonary genes released by ASC-derived EVs induce the expansion of Tregs, which leads to a decrease in the release of allergy-specific Th2 cytokines, eosinophil infiltration, and allergy-specific IgG1 and IgE production in asthmatic mice [19,23].