Tyrosine phosphorylation of STAT5 and STAT5 transcriptional target Fn14 were successfully inhibited in the orthotopic GBM6 tumors with 10 mg/kg of pimozide (Figure 2B), supporting STAT5 as a viable therapeutic target in EGFRvIII+ GBM. This evidence concerns the gene TNFRSF12A and glioblastoma.