Inhibition of mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibition also led to activation of the liver kinase B1/adenosine monophosphate (AMP)-activated protein kinase/Unc-51-like kinase 1 signaling axis, a key regulator of autophagy, in pancreatic cancer cells [10]. This evidence concerns the gene MAP4K1 and familial pancreatic carcinoma.