DES and heart disorder: Genetic architecture of ACM became more complex with the introduction of sequencing technologies, i.e., exome and genome sequencing, which led to the identification of numerous variants in cardiac disease-related or -unrelated non-desmosomal genes [6] such as Transmembrane protein 43 (TMEM43) [7], Desmin (DES) [8], Phospholamban (PLN) [9], Filamin C (FLNC) [10], Cadherin 2 (CDH2) [11,12] and Tight junction protein 1 (TJP1) [13].