Therefore, the purpose of the present study was to further investigate the diagnostic utility of selected MMPs, MMP-2, MMP-3, MMP-11 and MMP-26, in patients with OC, benign ovarian lesions (Serous cystadenomas) and healthy women in comparison to routinely used markers, HE4 and CA125, and in comparison, to the ROMA algorithm. This evidence concerns the gene MMP2 and serous cystadenoma.