GPER1 and breast cancer: Indeed, besides the well-known role of αER-mediated genomic and non-genomic pathways in enhancing breast cancer cell proliferation, survival, and invasion [65,66], a key role in estrogen-dependent responses and in the progression of breast cancer is played by GPR30 [67,68,69,70], and it has been previously demonstrated that GPR30 can mediate BPA estrogenic signals in ER-negative breast cancer cells [44,71].